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. 2020 May 12;10:700. doi: 10.3389/fonc.2020.00700

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Copyright © 2020 Yang, Ji, Teng, Cai, Wang, Wu, Lei, Lusvarghi, Ambudkar and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Sitravatinib inhibits ABCG2-mediated mitoxantrone transport. The accumulation of tritium-labeled mitoxantrone in NCI-H460 and NCI-H460/MX20 (A), S1 and S1-M1-80 (B). The ABCG2-mediated efflux activity in NCI-H460 (C), S1 (E) and their corresponding mitoxantrone-selected cell line NCI-H460/MX20 (D), S1-M1-80 (F) at a series of time points (0, 30, 60, 120 min). Data from at least three independent experiments are shown as mean ± SD. *p < 0.05 compared with control group.