Table 1.
SARS | MERS | SARS-CoV-2 | |
---|---|---|---|
Infected host cell | Alveolar epithelial cells Monocyte-macrophage Dendritic cells Activated T cells |
Alveolar epithelial cells Monocyte-macrophage Dendritic cells Activated T cells |
Respiratory epithelial cells T lymphocytes |
Suspectable for virus replication | Respiratory epithelial cells | Alveolar epithelial cells Monocyte-macrophage Dendritic cells Activated T cells |
Respiratory epithelial cells Unknown |
Monocyte-macrophage | Abortive replication Viral protein inhibition |
Viral replication Kill monocyte-macrophage |
Unknown |
Impacts on immune system | Indirectly kill: T cell apoptosis | Viral replication Directly killed T cell |
Unknown |