. Author manuscript; available in PMC: 2020 May 19.

Published in final edited form as: J Diabetes Clin Res. 2019;1(1):5–23. doi: 10.33696/diabetes.1.003

Table 2:

Circulating microRNA profile changes reported in animal models of diabetes mellitus.

Animal Models	Source	miRNA Detection Methods	miRNA Expression Alteration		Reference
T1DM Model
Streptozotocin (STZ)-induced mice	Plasma	qRT-PCR	Up	miR-375	52
Non-obese diabetic (NOD) mice	Plasma	qRT-PCR	Up	miR-375	52
T2DM Model
High fat diet (HFD), STZ-induced rats	Blood	miRNA microarray, confirmed by qRT-PCR	Up	miR-29a, miR-144, miR-150, miR-192, miR-320a	34
High fat diet (HFD), STZ-induced rats	Blood	miRNA microarray, confirmed by qRT-PCR	Down	miR-30d, miR-146a, miR-182	34
Zucker diabetic fatty (ZDF) rats	Plasma	qRT-PCR	Up	miR-122, miR-133, miR-210 and miR-375	54
Zucker diabetic fatty (ZDF) rats	Plasma	qRT-PCR	Down	miR-140, miR-151–3p, miR-185, miR-203, miR-434–3p, miR-450a	54
db/db mice	Serum	qRT-PCR	Up	miR-15b, miR-146b, miR-486	46