. Author manuscript; available in PMC: 2020 May 19.

Published in final edited form as: J Diabetes Clin Res. 2019;1(1):5–23. doi: 10.33696/diabetes.1.003

Table 3:

Pancreatic islets microRNA profile changes reported in clinical study on diabetic patients.

Study Design		miRNA Detection Methods	miRNA Expression Alteration		References
Non-Diabetic Donors	Diabetes Patients	miRNA Detection Methods	miRNA Expression Alteration		References
Type 1 Diabetes Mellitus
4	2	qRT-PCR	Up	miR-125a-5p	59
Type 2 Diabetes Mellitus
10	5	qRT-PCR	Up	miR-124a	60
9	11	Global profilingTaqMan array, comfirmed by qRT-PCR	Up	miR-187	61
10	9	qRT-PCR	Down	miR-7a	62
19	12	qRT-PCR	Down	miR-184	63
3	4	Global miRNA Seq	Up	miR-187, miR-216a, miR-589	64
3	4	Global miRNA Seq	Down	miR-7–1, miR-7–3, miR-23c, miR-30a, miR-369, miR-487a, miR-487b, miR-495, miR-539, miR-544a, miR-656, miR-4716
14	10	qRT-PCR	Down	miR-136, miR-369, miR411, miR-432, miR-487a, miR-487b, miR-655, miR-656