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. 2020 May 12;12:93. doi: 10.3389/fnagi.2020.00093

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Copyright © 2020 Tu, Jiang, Zhang, Wan, Li, Pan, Manavis and Yan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Lack of sorfra plaques in the striatum and diencephalon in an AD brain exhibited Thal phase 5 and Braak V stage neuropathologies. Section orientation, anatomical regions, figure panel arrangement, and scale bars are as indicated in individual panels. (A) A low-magnification image of the immunolabeled section (counterstained with toluidine blue) at the level of the mammillary nucleus (MN), displaying sortilin C-terminal (CT) antibody labeling in multiple telecephalic and diencephalic structures. Framed areas in (A) are enlarged and shown as (B–I). Sorfra plaques are present in the insular cortex (iCtx) (B,C) and the amygdaloid complex (Amyg) (D). Large neuronal somata are labeled in the nucleus basalis of Meynert (NBM), while no plaque profiles are seen in this basal forebrain nucleus (E). There are also no sorfra plaques present in the claustrum (Cla), and all the striatal, thalamic, and hypothalamic subregions, such as the putamen (Pu) (F), the external (GPe) and internal (GPi) divisions of the globus pallidus (GP) (A,G), the dorsal (MDd) and medial (MDm) divisions of the mediodorsal nucleus (MD) of thalamus (A,H), and the lateral (LHN) and medial (MHN) hypothalamic nucleus (HN) (A,I). Abbreviations: EC, external capsule; Fx, fornix; IC, internal capsule; VL, ventrolateral thalamic nucleus; VM, ventromedial thalamic nucleus; Cpd, cerebral peduncle; OT, optic tract; 3V, third ventricle; PV, paraventricular nucleus; WM, white matter.