FIGURE 12.

Distribution of pTau-immunoreactive neuronal profiles in the cerebral, striatal, and diencephalic subregions in an AD brain exhibited Thal phase 5 and Braak V stage neuropathologies. Section orientation, anatomical regions, figure panel arrangement, and scale bars are as indicated. (A) A whole section view of pTau immunolabeling (with toluidine blue counterstain) at low magnification, with the framed areas enlarged and shown as (B–I). Phosphorylated tau-immunoreactive neuronal profiles and neuritic clusters are present in the insular cortex (A,B), claustrum (A), and amygdala (A,C), with some labeled neurons appeared to be tangled (as pointed by arrows). In the NBM, large-sized putative cholinergic neurons exhibit strong IR (as pointed by arrows), whereas neuritic clusters are rarely found (D). In both the putamen and GP, neither labeled neuronal nor neuritic profiles are visualized (E,F). In the thalamus and hypothalamus, a small number of pTau-immunoreactive neurons (as pointed by arrows) are found, mostly localized to the paraventricular (PV) region (G–I). Abbreviations are as defined in Figure 10.