FIGURE 3.

Differential distribution of sorfra plaques, β-amyloid deposition, and tauopathy in the frontal lobe from a brain with Thal phase 1 and Braak stage III neuropathologies. Section orientation (in A, M: medial, I: inferior), figure panel arrangement, neuroanatomical structures, and scale bars are as indicated. (A–E) Low- and high-power views of plaque-like and cellular labeling visualized by the C-terminal antibody. A small amount of sorfra plaques are observed in the basal cortical areas including the anterior orbit gyrus [OrG(a)] and lateral orbit gyrus [OrG(l)] (A–C). In other parts of the frontal lobe including the inferior, middle, and superior frontal gyri (IFG, MFG, SFG), no sorfra plaques are recognizable, whereas labeled neuronal somata are present (A,D,F). (F–J) Low- and high-power views of Aβ immunolabeling in an adjacent section. Compact and diffuse plaques are present in all cortical gyri with a comparable density (fairly low) (G–J). (K–O) pTau immunolabeling in other neighboring sections. Only a few individual immunoreactive neurons are identifiable by close examination of the image at high magnification, which are located in the basal part of the frontal lobe (L–O). Abbreviations: sfs, superior frontal sulcus; imfs, intermediate frontal sulcus; ifs, inferior frontal sulcus; WM, white matter.