FIGURE 4.

Distribution of sorfra plaques, β-amyloid deposition, and β-secretase 1 (BACE1)-labeled dystrophic neurites in frontal sections of the occipital lobe (OL) in a brain with Thal phase 1 and Braak stage III neuropathologies. Section orientation (in A, M: medial, I: inferior), figure panel arrangement, neuroanatomical structures, and scale bars are as indicated. The broken blue lines mark the border between areas 17 and 18. (A–D) Low- and high-power views of sorfra plaques. Sorfra plaques are mostly localized to the basal cortical areas including the lateral and medial occipitotemporal gyri [OTG(l), OTG(m)] and occasionally found in area 18 (A–D). Only several plaques could be identified across the entire area 17 by scanning the image at high magnification. Labeled neuronal somata are seen at closer examination (D, insert). (E–H) Low- and high-power views of Aβ immunolabeling in an adjacent section. Compact and diffuse plaques are present in all cortical gyri with a comparable density (G–J). Cerebral amyloid angiopathy (CAA) and meningeal Aβ deposition are found at some locations (H and enlarged insert). (I–L) The distribution and morphology of BACE1 immunoreactive dystrophic neurites, which are all found in the cortex of all gyri with comparable density. At high magnifications, these dystrophic neurites occur as isolated spherical profiles or rosette-like clusters (J–L, examples are pointed by arrows). Abbreviations: CG, cuneate gyrus; LG, lingual gyrus; LV, lateral ventricle; WM, white matter; cs, calcarine sulcus; col-s, collateral sulcus; ots, occipitotemporal sulcus; I–VI, cortical layers.