FIGURE 5.

Distribution of sorfra plaques, β-amyloidosis, and tauopathy in the temporal lobe structures in a brain with Thal phase 4 and Braak stage IV neuropathologies. Section orientation, figure panel arrangement, neuroanatomical structures, and scale bars are as indicated. (A–E) Low- and high-power views of sorfra plaques. They are found frequently in the neocortical, entorhinal, and hippocampal subregions. The density of these plaques is comparable among the temporal neocortical gyri. Heavily stained plaques are present from the Pre-S, Sub, and Pro-S, to CA1. Sorfra plaques are also seen in the DG. They arrange as a row in the stratum radiatum (s.r.) of the Sub and the molecular layer (ML) of the DG (A–C). Labeled neuronal somata and dendritic processes are seen at high magnifications (D,E). (F–J) Aβ immunolabeling in a neighboring section. Note that the distribution and density of β-amyloid plaques appear comparable to that of sorfra plaques. However, diffuse parenchymal, vascular, and meningeal amyloidosis are visualized in Aβ labeling. (K–O) pTau immunolabeling in another neighboring section. Phosphorylated tau-positive neuronal somata are densely packed in CA1 and subicular subregions and frequently observed in the neocortical areas (L–O). Most of these neurons appear tangled (M,O, examples are pointed by arrowheads and shown with enlarged insert). Abbreviations are as defined in Figure 1.