FIGURE 7.

Correlative assessment of plaque and tangle pathologies using multiple markers in the visual cortex (VC) in a brain with Thal phase 4 and Braak stage IV neuropathologies. Section orientation, figure panel arrangement, neuroanatomical structures, and scale bars are as indicated. The border of areas 17 and 18 is marked by a broken blue line for each type of labeling (A,D,G,J,M). (A–C) Low- and high-power views of the distribution and morphology of sorfra plaques in areas 17 and 18. Sorfra plaques are more densely distributed but more heavily labeled in area 18 than in area 17 (B,C, examples are indicated by arrows). (D–F) Aβ immunolabeling in a neighboring section of the VC. The amount of β-amyloid plaques appears to be greater in area 17 than in area 18. In the striate cortex, β-amyloid deposition appearing as compact and diffuse-like plaques over the sublayers of IV, whereas the lesions in area 18 occur largely as compact-like plaques (E,F). (G–I) Low- and high-magnification images of BACE1 immunolabeling, with the pathological profiles representing dystrophic neurites arranged as clusters or isolated swollen neurites. At high magnification, the neuritic clusters are largely distributed in the deeper layers of the cortex (i.e., III–VI) in both areas 17 and 18, including the sublayers of IV in the former (H,I, as pointed by arrows). (J–L) Low- and high-magnification views of silver-stained neuritic plaques in the primary and secondary visual cortical areas. At high magnification, the neuritic clusters are largely distributed in the deeper layers of the cortex (i.e., III–VI) in both areas 17 and 18, as pointed by arrows. Silver-stained neuronal somata are rarely observed in both visual centers. (M–O) pTau immunolabeling in a neighboring section. There exist a few pTau-labeled neuronal somata in area 18, whereas pTau-positive neuronal processes are occasionally encountered in areas 17 and 18 by close examination of the entire section (N,O, inserts). Abbreviations are as defined in Figure 4.