Table 1.

RF values for different mutant and corresponding wildtype sequences from HIVdb [30]

Mutation		Background polymorphisms	RF
			IDV	SQV	LPV	FPV
M46I
Wildtype [33]		V3I, S37N, A71V	0.6, 1.0, 1.2	–	–	0.3, 0.6, 0.7
Mutant [83]			4.4	–	–	2.2
I50L
Wildtype [33]		V3I, S37N, A71V	0.6, 1.0, 1.2	–	–	0.3, 0.6, 0.7
Mutant [33]			0.1, 0.3, 0.3	–	–	0.2, 0.2, 0.3
I84V
Wildtype [84]		V3I, L10F, S37N	1.5	1.3	1.6	1.8
Mutant [84]			2.1, 3.2	2.7, 3.7	6.2, 7.7	4.6, 8.4
N88S
Wildtype [6]		V3I, S37N, L63P, R57G/L77Ia	1.1	–	–	1.0
Mutant [6]			2.6	–	–	0.1

First column indicates the mutation analysed, while the second column indicates background polymorphisms that are present in both wildtype and mutant sequences compared to the reference HIV sequence HXB2. Multiple RF measurements for the same protein are separated by comma. M46I wildtype and mutant measurements reported from different studies, but performed using the same susceptibility test method (Phenosense, Monogram, San Francisco, USA)

^a Indicates that the R57G background mutation was found in sequences where RF for IDV was measured and L77I in sequences where RF for FPV was measured