%BIAS vs %SD tradeoff curves calculated across the 35 lesions for iterations 5 to 100 (every 5th iteration) for the three reconstruction methods investigated in this work and the post-reconstruction deconvolution approaches. Left: Spherical VOIs centered at the true lesion coordinates. Right: Spherical VOIs centered on the coordinate for which the corresponding lesion mean activity concentration is maximal (a clearer aspect of the curves, except for noRM, can be viewed in the zoomed inset). The black arrows indicate the direction of increasing iterations. noRM, invRM, and varRM are reconstructions without, with spatially-invariant, and with spatially-variant resolution modeling, respectively. varLW and varRL are respectively Landweber and Richardson-Lucy post-reconstruction deconvolution approaches using the same spatially-variant kernels as the varRM reconstruction approach.