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. 2020 May 19;12:69. doi: 10.1186/s13148-020-00839-z

Table 3.

EC50 values of MAKV-8 and SAHA towards acetylated targets

Target EC50 (μM)
MAKV-8 SAHA
Acetyl α-tubulin 12.1 ± 0.9 1.9 ± 0.8
Acetyl histone H4 5.9 ± 1.4 2.6 ± 0.2

Data are presented as the mean ± standard deviation of the effective concentration that induces half-maximal acetylation of protein targets (EC50). Values were calculated after western blot quantification from at least three independent experiments. Concentrations of compounds near the EC50 values have been used for subsequent experiments