Figure 3:

(A) HC-MEIOSIS pulse sequence for simultaneous acquisition of two pairs of ¹³C and ¹H detected dual-receiver experiments. The phase cycle is set to, ϕ1=y, −y; ϕ2=x, x, −x, −x; ϕrec=y, −y, −y, y. (B) 1D HC-MEIOSIS spectra of GB1 protein obtained from the first increment of HC-MEIOSIS pulse sequence, and n=4 (Table 1). The corresponding integrated S/N values are indicated. (C) 2D HC-MEIOSIS spectra of GB1 protein, (H)CXCX, (H)N(CA)CX, (H)CA(N)H, and (H)NH acquired simultaneously using the pulse sequence in A. The 1D cross sections along the dotted lines are shown for ¹³C and ¹H detected 2D spectra. The corresponding single receiver experiments were shown in references^24,28.