Table 3. Hazard ratios of left ventricular mass and its several indexations for adverse clinical outcomes.
Univariate | Multivariate | |||
---|---|---|---|---|
HR (95% CI) | P | HR (95% CI) | P | |
Composite outcome | ||||
LVM (g) | 1.007 (1.005–1.008) | <0.001 | 1.004 (1.002–1.005) | <0.001 |
LVMI-BSA (g/m2) | 1.019 (1.015–1.022)* | <0.001 | 1.011 (1.006–1.016)* | <0.001 |
LVMI-H2.7 (g/m2.7) | 1.042 (1.033–1.051)* | <0.001 | 1.023 (1.012–1.035)* | <0.001 |
Renal outcome | ||||
LVM (g) | 1.009 (1.007–1.011)* | <0.001 | 1.006 (1.003–1.009)* | <0.001 |
LVMI-BSA (g/m2) | 1.022 (1.017–1.026)* | <0.001 | 1.015 (1.009–1.020)* | <0.001 |
LVMI-H2.7 (g/m2.7) | 1.049 (1.039–1.059)* | <0.001 | 1.032 (1.019–1.045)* | <0.001 |
CV outcome | ||||
LVM (g) | 1.006 (1.003–1.008) | <0.001 | 1.005 (1.000–1.009) | 0.037 |
LVMI-BSA (g/m2) | 1.014 (1.009–1.019) | <0.001 | 1.010 (1.002–1.017) | 0.012 |
LVMI-H2.7 (g/m2.7) | 1.031 (1.020–1.043) | <0.001 | 1.023 (1.006–1.040) | 0.007 |
All-cause mortality | ||||
LVM (g) | 1.006 (1.002–1.009) | 0.001 | 1.001 (0.995–1.006) | 0.765 |
LVMI-BSA (g/m2) | 1.014 (1.007–1.021) | <0.001 | 0.999 (0.990–1.009) | 0.905 |
LVMI-H2.7 (g/m2.7) | 1.026 (1.010–1.042) | 0.001 | 0.996 (0.975–1.018) | 0.710 |
LVM, left ventricular mass; LVMI, left ventricular mass index; BSA, body surface area; H, height; W, weight; CV, cardiovascular. HR and its CI were calculated using Cox proportional hazard regression analysis. In multivariate analysis, covariates were age, sex, current smoking, causes of chronic kidney disease, systolic blood pressure ≥ 127 mmHg, diastolic blood pressure ≥ 77 mmHg, blood urea nitrogen≥ 8.6 mmol/l, estimated glomerular filtration rate ≥ 46.3 ml/min/1.73m2, bilirubin ≥ 10.3 μmol/l, albumin ≥ 42 g/l, cholesterol ≥ 4.4 mmol/l, hemoglobin ≥ 12.8 g/dl, body mass index, fasting glucose, urine protein creatinine ratio, and high sensitive C-reactive protein.
* meant results using time-dependent Cox hazard regression analysis.