Table 3. NOX1 protein expression in human malignant and benign tissue.

Organ	Pathologic diagnosis	Unstained, unscored 0+ (No. [%])	Low expressers 1+ (No. [%])	High expressers 2+, 3+ (No. [%])	P value1 (statistical significance)	% cells positive
						0‒9%	10‒24%	25‒49%	≥50%
Colon	Colon carcinoma	43 [29]	52 [36]	51 [35]	0.0 (***p)	29	10	12	49
	Colon adenoma	2 [6]	14 [44]	16 [50]	0.0004 (***p)	6	3	0	91
	Colon polyp	1 [8]	8 [67]	3 [25]	0.0314 (*p)	8	0	17	75
	Inflammatory lesions	0 [0]	11 [85]	2 [15]	0.0853 (n.s.)	0	8	8	85
	Normal colon	0 [0]	18 [100]	0 [0]		0	0	44	56
Small intestine	Small intestine carcinoma	56 [51]	37 [34]	17 [15]	0.0137 (*p)	51	20	12	17
	Small intestine inflammatory lesions	30 [88]	3 [9]	1 [3]	0.1562 (n.s.)	88	0	6	6
	Normal small intestine	25 [76]	8 [24]	0 [0]		76	0	12	12
Prostate	Prostate carcinoma	180 [98]	0 [0]	3 [2]	0.7328 (n.s.)	98	0	1	1
	Normal prostate	7 [100]	0 [0]	0 [0]		100	0	0	0
Ovary	Ovarian carcinoma	155 [95]	6 [4]	2 [1]	0.9497 (n.s.)	95	0	2	2
	Normal ovarian tissue adjacent to cancer	2 [100]	0 [0]	0 [0]		100	0	0	0
Lung	Lung carcinoma	143 [99]	1 [1]	0 [0]	0.5972 (n.s.)	99	0	1	0
	Normal lung	40 [100]	0 [0]	0 [0]		100	0	0	0
Stomach	Gastric carcinoma	14 [82]	1 [6]	2 [12]	0.0735 (n.s.)	82	0	0	18
	Gastric inflammatory lesions	38 [90]	4 [10]	0 [0]		90	7	0	2
Breast	Breast carcinoma	162 [80]	33 [16]	8 [4]	0.8514 (n.s.)	80	0	0	19
	Normal breast	6 [86]	1 [14]	0 [0]		86	0	0	14

Tissues were scored as unstained (0+), low NOX1 expressers (1+), or high NOX1 expressers (2+, 3+). Percentage of tissues per score is shown in brackets. n.s., not statistically significant.

¹The Chi-square statistical test was used to determine significant differences between the proportions of low (1+) and high expressers (2+, 3+) between malignant tissue and matched or adjacent normal tissue.