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. Author manuscript; available in PMC: 2020 May 19.
Published in final edited form as: Cell Rep. 2019 Apr 2;27(1):59–70.e4. doi: 10.1016/j.celrep.2019.03.015

Figure 5. Hop RNAi Suppresses mHtt-Mediated Arrhythmicity, Aggregate Formation, and Cell Loss.

Figure 5.

(A) Rhythmicity (P-S) is indicated for various genotypes, including flies expressing HttQ128 in PDF neurons in a TRiP RNAi library control background (HttQ128 TRiP Ctrl) and expressing two independent Hop TRiP RNAi lines (HttQ128 Hop RNAi TRiP #1 and #2; n = 17–19).

(B) Rhythmicity (P-S) is indicated for various genotypes, including flies expressing TDP43A315T in PDF neurons in a TRiP RNAi library control background (TDP43A315T TRiP Ctrl) and expressing Hop RNAi lines (TDP43A315T Hop TRiP #2; n = 11–22).

(C) The number of sLNvs present per brain hemisphere is indicated for various genotypes where either Hop RNAi (TRiP) or TRiP control and HttQ128 expression are shown (n = 18–19).

*p < 0.05, **p < 0.01, ***p < 0.005.