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. 2020 May 15;13:4201–4211. doi: 10.2147/OTT.S227395

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© 2020 Zhang et al.

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E6 downregulates SMG1 expression via DNMT1. (A) The mRNA expression of DNMT1 and SMG1 in HPV-positive cells and HPV-negative cells was detected by RT-qPCR. (B) The protein expression of DNMT1 and SMG1 in HPV-positive cells and HPV-negative cells were detected by Western blot. (C) The mRNA expression of DNMT1 and SMG1 when E6 overexpression in the FaDu and UM-SCC-4 cells was detected by RT-qPCR. (D) The mRNA expression of DNMT1 and SMG1 when E6 silenced in the UM-SCC-47 and UPCI-SCC-090 cells were detected by RT-qPCR. (E) The protein expression of DNMT1 and SMG1 when E6 overexpression in the FaDu and UM-SCC-4 cells and E6 silenced in the UM-SCC-47 and UPCI-SCC-090 cells were detected by Western blot. *P < 0.05.