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. 2020 May 15;13:4201–4211. doi: 10.2147/OTT.S227395

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© 2020 Zhang et al.

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The regulatory effect of DNMT1 on SMG1. (A) The mRNA expression of SMG1 and DNMT1 was detected when DNMT1 was overexpressed by RT-qPCR. (B) The mRNA expression of SMG1 and DNMT1 was detected when DNMT1 was silenced by RT-qPCR. (C) The protein expression of SMG1 and DNMT1 was detected when DNMT1 was overexpressed and when DNMT1 was silenced by Western blot. (D) The protein expression of DNMT1 after Azacitidine treatment. (E) Rescue assay detected E6 downregulates SMG1 expression via DNMT1. *P < 0.05.