Table 3.
Performance of the Two Models Compared with Staging Systems
| Model | Training Cohort | Validation Cohort | ||||
|---|---|---|---|---|---|---|
| C-index (95% CI) | tdAUC | IBS | C-index (95% CI) | tdAUC | IBS | |
| Model-pre | 0.698 (0.659–0.737) | 0.727 | 0.188 | 0.673 (0.622–0.724) | 0.730 | 0.186 |
| Model-post | 0.728 (0.691–0.765) | 0.783 | 0.172 | 0.713 (0.661–0.765) | 0.779 | 0.169 |
| BCLC stage | 0.610 (0.458–0.762) | 0.528 | 0.217 | 0.595 (0.427–0.763) | 0.530 | 0.214 |
| HKLC stage | 0.623 (0.548–0.698) | 0.588 | 0.211 | 0.630 (0.529–0.730) | 0.593 | 0.211 |
| CLIP classification | 0.640 (0.575–0.706) | 0.601 | 0.211 | 0.634 (0.508–0.738) | 0.613 | 0.207 |
| AJCC TNM (8th) | 0.684 (0.598–0.770) | 0.587 | 0.210 | 0.623 (0.508–0.738) | 0.553 | 0.216 |
Note: The tdAUC represented the median value of AUCs at various time points.
Abbreviations: C-index, concordance index; CI, confidence interval; tdAUC, time-dependent area under the receiver operating characteristic curve; IBS, integrated Brier score; BCLC, Barcelona Clinic Liver Cancer; HKLC, Hong Kong Liver Cancer; CLIP, Cancer of the Liver Italian Program; AJCC, American Joint Committee on Cancer; TNM, tumor-node-metastasis.