Table 4.
Median RFS and Cumulative Recurrence Rate According to Each Risk Group Defined by Two Models
| Model | Cohort | Group | N | Median RFS, Months (95% CI) | 2-Year Recurrence Rate, % (95% CI) | 5-Year Recurrence Rate, % (95% CI) | Hazard Ratio (95% CI) | P value* |
|---|---|---|---|---|---|---|---|---|
| Model-pre | Training | Low-risk | 173 | 95.1 (82.4-NA) | 14.6 (9.2–19.8) | 35.7 (26.7–43.5) | Reference | |
| High-risk | 150 | 22.9 (18.9–35.9) | 3.346 (2.421–4.624) | < 0.001 | ||||
| Validation | Low-risk | 94 | 98.7 (63.3-NA) | 14.9 (7.4–21.8) | 38.3 (27.1–47.8) | Reference | ||
| High-risk | 68 | 30.0 (20.1–44.3) | 44.1 (31.0–54.8) | 75.2 (60.1–84.6) | 3.202 (2.020–5.075) | < 0.001 | ||
| Model-post | Training | Low-risk | 275 | 73.9 (56.9-NA) | 22.3 (17.2–27.1) | 45.6 (38.3–52.1) | Reference | |
| High-risk | 48 | 10.2 (6.4–18.9) | 81.3 (66.2–89.6) | 95.7 (76.3–99.2) | 24.99 (13.52–46.20) | < 0.001 | ||
| Validation | Low-risk | 139 | 82.4 (56.9-NA) | 18.0 (11.3–24.1) | 44.8 (35.1–53.0) | Reference | ||
| High-risk | 23 | 8.8 (5.1–21.5) | 82.6 (57.6–92.9) | 100.0 (NA-NA) | 83.81 (32.07–219.0) | < 0.001 |
Note: *Calculated by using the Log rank test.
Abbreviations: RFS, recurrence-free survival; CI, confidence interval; NA, not applicable.