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. 2020 Apr 14;5(2):e10160. doi: 10.1002/btm2.10160

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© 2020 The Authors. Bioengineering & Translational Medicine published by Wiley Periodicals, Inc. on behalf of The American Institute of Chemical Engineers.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Systemic biodistribution of G4 and G6 dendrimers in glioblastoma. Fluorescently labeled G4 and G6 dendrimers were injected intravenously into GL261 brain tumor bearing mice. Plasma and organs were collected at specified time points, homogenized to extract dendrimers, and measured via fluorescence spectrometry. (a) G6 dendrimers exhibit higher plasma concentration over time than G4 dendrimers. (b) G6 dendrimers have greater levels in the systemic organs compared to G4 due to their longer circulation time except in kidneys, where their increased size enables decreased elimination from renal clearance. ***p < .001