Figure 5.

Current model of the MLV nuclear export and its impact on the outcome of the FL RNA in the cytoplasm. The model proposed is based on our present results and published data (arrow in full line) as well as hypothesis (dotted arrow). Briefly, the FL RNA is firstly driven to the NXF1 pathway probably because of its methylation. Because of cis element structures present in pol gene [14,16], NXF1 interacts with FL RNA and drives it through the nuclear pore until to reach the MTOC [44]. Then, FL RNA is directed until polysome [14] and is translated in Gag proteins. If a few amount of Gag proteins could reach the nucleus [39], it could serve as viral partner for CRM1 interaction to export FL RNA. Then, FL RNA complexed to Gag targets the packaging sites at the plasma membrane to form neo particles.