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Yap ablation inhibits AKT/c-Met/SNAI1-induced liver tumor formation. A, Study design. B, Survival curve. C, Liver weight and liver/body ratio of Yapflox/flox mice injected with AKT/c-Met/pT3 or AKT/c-Met/SNAI1. D, Representative gross and hematoxylin and eosin (H&E), CK19, and Ki-67 staining images of livers from Yapflox/flox mice injected with AKT/c-Met/SNAI1/pCMV or AKT/c-Met/SNAI1/Cre plasmids. Scale bar, 100 μm. ***, P < 0.01; ****, P < 0.0001. W.p.i., weeks post injection.
