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. Author manuscript; available in PMC: 2020 Nov 1.
Published in final edited form as: Cancer Res. 2019 Aug 5;79(21):5563–5574. doi: 10.1158/0008-5472.CAN-18-3750

Figure 6.

Figure 6.

Inhibition of the canonical Notch signaling suppresses AKT/c-Met/SNAI1-induced CC-like phonotype in mice. A, Study design. B, Survival curve. C, Liver weight and liver/body ratio of the mice. D, Representative gross images, hematoxylin and eosin (H&E), CK19, and Ki-67 staining images of livers from mice injected with AKT/c-Met/SNAI1/pT3 or AKT/c-Met/SNAI1/dnRBPJ plasmids. Scale bar, 100 μm. E, Percentage of Ki-67–positive cells in liver tissues and percentage of Ck19-positive area fraction in mice liver tumor injected with AKT/c-Met/SNAI1/pT3 or AKT/c-Met/SNAI1/dnRBPJ plasmids. ***, P < 0.001. N.S., not significant; W.p.i., weeks post injection.