Table 2.
Significantly altered lipids
| Metabolite | Log2(control) | Log2(case) | p value | FDR | % Fold change |
|---|---|---|---|---|---|
| NEFA(22:5) | 8.78 ± 0.27 | 7.52 ± 0.33 | 0.001515 | 0.033614 | −14.31743265 |
| NEFA(24:1) | 9.15 ± 0.21 | 8.13 ± 0.31 | 0.0017857 | 0.033614 | −11.12784437 |
| LCer(24:1) | 7.78 ± 0.08 | 7.34 ± 0.11 | 0.0018148 | 0.033614 | −5.753291789 |
| LPC(20:2) | 9.06 ± 0.06 | 8.69 ± 0.09 | 0.00052268 | 0.030943 | −4.138335102 |
| LCer(16:0) | 10.57 ± 0.06 | 10.13 ± 0.10 | 0.00088813 | 0.032209 | −4.127533649 |
| PE(P-16:0/22:4) | 10.67 ± 0.07 | 10.28 ± 0.10 | 0.0034702 | 0.036819 | −3.61847002 |
| LPE(20:4) | 8.91 ± 0.06 | 8.59 ± 0.07 | 0.00038527 | 0.030943 | −3.610292601 |
| CE(24:0) | 11.52 ± 0.09 | 11.11 ± 0.11 | 0.0030654 | 0.03489 | −3.547716326 |
| Cer(20:0) | 7.68 ± 0.06 | 7.40 ± 0.07 | 0.0032393 | 0.035451 | −3.546116404 |
| LPC(17:0) | 11.36 ± 0.05 | 10.97 ± 0.08 | 0.00014128 | 0.030943 | −3.457629226 |
| PC(17:0/20:4) | 11.82 ± 0.07 | 11.42 ± 0.09 | 0.002219 | 0.033614 | −3.35741171 |
| PC(17:0/18:1) | 10.47 ± 0.06 | 10.14 ± 0.08 | 0.0023824 | 0.033614 | −3.20304988 |
| TAG53:6-FA20:4 | 7.59 ± 0.05 | 7.35 ± 0.07 | 0.0047343 | 0.045298 | −3.12092987 |
| Cer(16:0) | 8.86 ± 0.05 | 8.58 ± 0.07 | 0.0059226 | 0.049437 | −3.096206958 |
| LPC(15:0) | 10.13 ± 0.05 | 9.83 ± 0.08 | 0.0024855 | 0.033825 | −2.998355538 |
| PC(17:0/18:2) | 12.05 ± 0.05 | 11.70 ± 0.08 | 0.0027807 | 0.034136 | −2.876227347 |
| CE(22:0) | 10.02 ± 0.06 | 9.74 ± 0.08 | 0.0055482 | 0.047578 | −2.875955107 |
| LPC(20:4) | 12.12 ± 0.06 | 11.78 ± 0.08 | 0.00066194 | 0.031875 | −2.833247208 |
| TAG51:4-FA16:1 | 8.74 ± 0.04 | 8.53 ± 0.05 | 0.0029816 | 0.03489 | −2.447692333 |
| TAG56:8-FA20:4 | 11.48 ± 0.07 | 11.20 ± 0.07 | 0.0054754 | 0.047578 | −2.431224594 |
| Cer(24:1) | 11.27 ± 0.05 | 10.99 ± 0.07 | 0.0025927 | 0.034136 | −2.40946479 |
| Cer(22:0) | 10.90 ± 0.05 | 10.64 ± 0.06 | 0.0021259 | 0.033614 | −2.388285567 |
| PC(18:1/20:4) | 14.44 ± 0.06 | 14.12 ± 0.07 | 0.0020069 | 0.033614 | −2.216220196 |
| CE(17:0) | 13.39 ± 0.05 | 13.10 ± 0.07 | 0.0017626 | 0.033614 | −2.180721528 |
| NEFA(20:4) | 13.86 ± 0.06 | 13.56 ± 0.08 | 0.0048608 | 0.045298 | −2.164188978 |
| SM(20:1) | 13.28 ± 0.05 | 12.99 ± 0.07 | 0.0011837 | 0.032216 | −2.158837007 |
| TAG56:7-FA20:4 | 12.64 ± 0.05 | 12.40 ± 0.06 | 0.0037147 | 0.038121 | −1.898035015 |
| LPC(18:1) | 14.57 ± 0.05 | 14.32 ± 0.07 | 0.0036636 | 0.038121 | −1.681348124 |
| CE(20:4) | 18.04 ± 0.05 | 17.82 ± 0.07 | 0.0038012 | 0.03838 | −1.222413179 |
| TAG52:1-FA18:1 | 15.17 ± 0.05 | 15.43 ± 0.07 | 0.0027793 | 0.034136 | 1.713236292 |
| TAG52:1-FA16:0 | 14.67 ± 0.06 | 14.96 ± 0.08 | 0.001687 | 0.033614 | 1.944418393 |
| TAG50:2-FA18:2 | 15.18 ± 0.06 | 15.50 ± 0.09 | 0.0032829 | 0.035451 | 2.114527145 |
| TAG52:1-FA18:0 | 14.30 ± 0.06 | 14.62 ± 0.08 | 0.0010336 | 0.032209 | 2.212793769 |
| TAG54:0-FA18:0 | 9.15 ± 0.05 | 9.36 ± 0.06 | 0.00461 | 0.045091 | 2.279869606 |
| TAG54:3-FA20:3 | 9.32 ± 0.04 | 9.54 ± 0.06 | 0.0010983 | 0.032209 | 2.335706924 |
| DAG(16:0/16:0) | 10.18 ± 0.04 | 10.42 ± 0.07 | 0.0049268 | 0.045298 | 2.353844253 |
| TAG50:1-FA18:1 | 15.73 ± 0.07 | 16.13 ± 0.10 | 0.001065 | 0.032209 | 2.532191884 |
| TAG50:1-FA16:0 | 16.44 ± 0.08 | 16.88 ± 0.11 | 0.0012743 | 0.033238 | 2.672266116 |
| TAG54:1-FA20:1 | 8.42 ± 0.05 | 8.65 ± 0.05 | 0.001354 | 0.033614 | 2.734967661 |
| TAG54:1-FA16:0 | 9.25 ± 0.04 | 9.51 ± 0.05 | 0.00017355 | 0.030943 | 2.783365984 |
| TAG48:1-FA18:1 | 13.51 ± 0.09 | 13.91 ± 0.12 | 0.0042533 | 0.042263 | 2.918331137 |
| TAG54:5-FA22:5 | 9.76 ± 0.05 | 10.05 ± 0.07 | 0.0015687 | 0.033614 | 2.983386082 |
| TAG53:1-FA16:0 | 8.74 ± 0.05 | 9.00 ± 0.06 | 0.0024163 | 0.033614 | 3.049782827 |
| TAG50:1-FA18:0 | 12.11 ± 0.07 | 12.48 ± 0.11 | 0.0030653 | 0.03489 | 3.065694283 |
| TAG52:0-FA18:0 | 11.63 ± 0.06 | 12.00 ± 0.09 | 0.00046749 | 0.030943 | 3.180424891 |
| TAG48:1-FA14:0 | 13.20 ± 0.09 | 13.63 ± 0.12 | 0.0019504 | 0.033614 | 3.263747973 |
| TAG52:0-FA16:0 | 11.01 ± 0.06 | 11.37 ± 0.08 | 0.00059315 | 0.030943 | 3.267105816 |
| TAG52:3-FA20:3 | 10.12 ± 0.06 | 10.45 ± 0.10 | 0.0032846 | 0.035451 | 3.286875028 |
| TAG52:2-FA20:2 | 9.42 ± 0.06 | 9.73 ± 0.08 | 0.0029404 | 0.03489 | 3.325497646 |
| TAG52:1-FA20:1 | 9.30 ± 0.06 | 9.61 ± 0.07 | 0.00046754 | 0.030943 | 3.498632494 |
| TAG51:0-FA17:0 | 8.45 ± 0.06 | 8.76 ± 0.08 | 0.002781 | 0.034136 | 3.554896904 |
| TAG48:1-FA16:0 | 14.10 ± 0.10 | 14.60 ± 0.14 | 0.0023153 | 0.033614 | 3.601714649 |
| TAG50:0-FA16:0 | 13.54 ± 0.08 | 14.04 ± 0.12 | 0.00058382 | 0.030943 | 3.7388893 |
| TAG49:0-FA18:0 | 7.86 ± 0.08 | 8.15 ± 0.14 | 0.0047979 | 0.045298 | 3.753109428 |
| TAG51:0-FA16:0 | 8.98 ± 0.06 | 9.33 ± 0.08 | 0.0024164 | 0.033614 | 3.834911298 |
| TAG51:0-FA18:0 | 8.30 ± 0.07 | 8.62 ± 0.08 | 0.0022509 | 0.033614 | 3.905248088 |
| TAG50:3-FA20:3 | 8.05 ± 0.05 | 8.37 ± 0.17 | 0.0049929 | 0.045298 | 3.908510498 |
| TAG52:7-FA16:0 | 8.48 ± 0.06 | 8.82 ± 0.08 | 0.00091569 | 0.032209 | 4.049985051 |
| TAG50:0-FA18:0 | 12.15 ± 0.09 | 12.67 ± 0.12 | 0.0005839 | 0.030943 | 4.28559829 |
| TAG46:1-FA14:0 | 10.96 ± 0.11 | 11.45 ± 0.15 | 0.0051951 | 0.046459 | 4.462184493 |
| TAG50:0-FA14:0 | 7.94 ± 0.06 | 8.30 ± 0.08 | 0.00042461 | 0.030943 | 4.569745222 |
| TAG49:0-FA16:0 | 10.02 ± 0.09 | 10.49 ± 0.12 | 0.0020077 | 0.033614 | 4.690186781 |
| TAG54:6-FA22:6 | 9.70 ± 0.07 | 10.16 ± 0.11 | 0.00048272 | 0.030943 | 4.693395231 |
| TAG54:0-FA16:0 | 7.06 ± 0.06 | 7.39 ± 0.06 | 0.00012953 | 0.030943 | 4.706367554 |
| TAG47:0-FA15:0 | 8.07 ± 0.08 | 8.45 ± 0.15 | 0.0053337 | 0.047027 | 4.740641233 |
| TAG52:5-FA20:5 | 8.51 ± 0.06 | 8.92 ± 0.10 | 0.0022509 | 0.033614 | 4.912457436 |
| TAG48:0-FA14:0 | 10.32 ± 0.10 | 10.83 ± 0.13 | 0.001115 | 0.032209 | 4.935500085 |
| TAG48:0-FA16:0 | 13.19 ± 0.11 | 13.85 ± 0.16 | 0.0010184 | 0.032209 | 4.962787325 |
| TAG49:0-FA17:0 | 8.85 ± 0.08 | 9.29 ± 0.11 | 0.0021262 | 0.033614 | 5.001577158 |
| TAG47:0-FA16:0 | 9.16 ± 0.09 | 9.63 ± 0.12 | 0.0027423 | 0.034136 | 5.16498652 |
| TAG48:0-FA18:0 | 9.94 ± 0.10 | 10.46 ± 0.13 | 0.0020367 | 0.033614 | 5.194763489 |
| TAG52:6-FA22:6 | 7.90 ± 0.07 | 8.35 ± 0.10 | 0.00074973 | 0.032209 | 5.694221781 |
| TAG46:0-FA16:0 | 11.35 ± 0.14 | 12.06 ± 0.19 | 0.0022508 | 0.033614 | 6.258605708 |
| TAG46:0-FA14:0 | 10.46 ± 0.13 | 11.16 ± 0.17 | 0.001132 | 0.032209 | 6.695044875 |
| TAG44:0-FA16:0 | 9.52 ± 0.14 | 10.17 ± 0.17 | 0.0059229 | 0.049437 | 6.783708462 |
Data are shown as mean ± SE, presented in ascending order of % fold change
DAG, diacylglycerol; FA, fatty acid