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. Author manuscript; available in PMC: 2021 Apr 1.
Published in final edited form as: Curr Opin Chem Biol. 2020 Mar 29;55:189–201. doi: 10.1016/j.cbpa.2020.02.008

Figure 1. Schematic protein domain structure for the four families of fungal iron regulators.

Figure 1.

DNA-binding domains (either Zn-finger or bZIP) are shaded in blue with specific Zn-finger binding residues shown in blue text. CBC-binding regions are shaded in purple. Coiled-coil regions are shown in gray. Confirmed Fe-S binding domains are shaded dark orange with specific Fe-S binding residues in red text. Putative Fe-S binding domains and other Cys-rich regions are shaded in light orange. A conserved C-terminal region in HapX/Hap43 regulators that is required for their response to iron starvation is shaded in green. Sc, S. cerevisiae; Cg, C. glabrata; Sp, S. pombe; An, A. nidulans; Af, A. fumigatus; Ca, C. albicans; Cn, C. neoformans.