Table 2.

Significant regions (as percentage of vertices, %) and average effect size (d) of differences in radial distance (RD) and Jacobian determinant (JD) common across splits 1 and 2, across Models I – III.

Model	Contrast	Region		Radial Distance (RD)				Jacobian Determinant (JD)
				Percentage of total region (%)	d*	draw*	p	Percentage of total region (%)	d*	draw*	p
I	Dependent users vs. non-dependent controls	Left	Amygdala	0	-	-	-	0.66	−0.128	−0.141	0.009
			Hippocampus	3.24	−0.146	−0.162	0.005	28.70	−0.155	−0.169	0.005
			Thalamus	0.04	−0.127	−0.167	0.008	0.36	−0.152	−0.177	0.003
		Right	Accumbens	10.65	−0.143	−0.174	0.005	0	-	-	-
			Amygdala	3.51	−0.172	−0.178	0.002	7.02	−0.149	−0.148	0.004
			Hippocampus	1.04	−0.146	−0.137	0.004	22.06	−0.164	−0.171	0.003
			Putamen	0	-	-	-	0.76	−0.150	−0.181	0.004
			Thalamus	1.76	−0.138	−0.154	0.005	2.32	−0.167	−0.163	0.002
II	Alcohol-dependent users vs. non-dependent controls	Left	Hippocampus	4.68	−0.168	−0.188	0.004	31.53	−0.170	−0.184	0.004
			Putamen	6.59	−0.155	−0.153	0.005	3.68	−0.143	−0.173	0.006
		Right	Accumbens	0	-	-	-	1.94	−0.156	−0.188	0.004
			Amygdala	9.28	−0.163	−0.165	0.004	7.38	−0.158	−0.163	0.005
			Hippocampus	4.64	−0.160	−0.168	0.003	29.30	−0.172	−0.177	0.003
			Putamen	14.91	−0.155	−0.201	0.004	9.11	−0.156	−0.199	0.004
			Thalamus	8.63	−0.166	−0.167	0.004	16.39	−0.154	−0.175	0.004
III	Nicotine-dependent users vs. non-smoking controls	Left	Amygdala	0.95	0.137	0.112	0.006	0	-	-	-
			Hippocampus	5.84	0.150	0.167	0.005	45.24	0.166	0.173	0.003
			Putamen	6.75	0.155	0.181	0.004	6.59	0.158	0.183	0.003
			Thalamus	0	-	-	-	3.60	0.153	0.160	0.003
		Right	Accumbens	3.55	0.161	0.182	0.003	9.14	0.141	0.166	0.006
			Amygdala	1.10	0.148	0.167	0.003	0	-	-	-
			Caudate	0.28	0.140	0.186	0.004	0	-	-	-
			Hippocampus	0.40	0.150	0.158	0.004	5.68	0.159	0.158	0.003
			Putamen	1.20	0.135	0.160	0.006	2.64	0.140	0.165	0.006
			Thalamus	9.11	0.157	0.160	0.003	7.43	0.165	0.159	0.002
	Smoking controls vs. non-smoking controls	Left	Hippocampus	3.92	0.194	0.218	0.004	29.06	0.202	0.227	0.005
			Putamen	0.80	0.201	0.247	0.002	2.72	0.188	0.234	0.005
			Thalamus	0.03	0.189	0.240	0.004	2.32	0.182	0.219	0.006
		Right	Accumbens	13.23	0.195	0.238	0.005	2.69	0.201	0.141	0.003
			Amygdala	0	-	-	-	0.365	0.207	0.193	0.002
			Hippocampus	0.68	0.205	0.193	0.002	9.67	0.210	0.215	0.004
			Pallidum	0	-	-	-	0	-	-	-
			Putamen	0	-	-	-	0.40	0.175	0.231	0.007
			Thalamus	4.52	0.193	0.210	0.004	5.875	0.214	0.222	0.002

^*Average effect size (d) computed over remaining significant regions after overlap of splits 1 and 2. Raw effect size (d_raw) represents effect size without correcting for covariates (age, sex, intracranial volume)