Table 2.

Allelic association tests reaching significance^* in overall or sex-specific analyses, in immune-mediated, autoimmune, and allergic diseases

		African American			Caucasian			Hispanic
Gene/SNP	Sample	OR	L95	U95	OR	L95	U95	OR	L95	U95
		Immune-mediated disease
PTPN22 / rs3811021	Overall	1.17	0.81	1.69	1.39a	1.12	1.72	1.10	0.60	2.02
	Males	1.32	0.68	2.53	1.50b	1.12	2.02	2.14	0.64	7.17
	Females	1.11	0.71	1.75	1.21	0.88	1.67	0.96	0.46	2.01
		Allergic disease
PTPN22 / rs3811021	Overall	0.86	0.59	1.24	1.39c	1.12	1.71	1.20	0.63	2.27
	Males	1.32	0.66	2.64	1.62d	1.19	2.20	2.00	0.53	7.55
	Females	0.70	0.44	1.11	1.14	0.84	1.55	1.07	0.51	2.28
		Autoimmune disease
PTPN22 / rs2476601	Overall	0.79	0.27	2.26	1.55	1.12	2.15	0.24	0.03	1.82
	Males	0.83	0.11	6.53	1.17	0.68	2.00	NE	NE	NE
	Females	0.81	0.24	2.79	1.99e	1.30	3.04	0.28	0.04	2.25

SNP = single nucleotide polymorphism; OR = odds ratio; L95 = Lower boundary of 95% confidence interval; U95 = Upper boundary of 95% confidence interval; NE = not estimable.

^*Boldface indicates significant effect after Holm-Bonferroni correction.

^ap=0.002;

^bp=0.007;

^cp=0.003;

^dp=0.002;

^ep=0.001;