Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Degradation of Cot1 in S. cerevisiae under low zinc conditions. When zinc levels are low, Cot1 is targeted for degradation in a manner that is dependent upon the Tul1 RING domain-containing E3 ligase and other members of the defective for SREBP cleavage (DSC) complex. While the signal that leads to the ubiquitination of Cot1 is unknown, polyubiquitination leads to its degradation via the vacuole membrane recycling and degradation pathway (vReD).
