Table 2.
Spearman correlations between metabolite ratios and temperature in regions of interest and clinical outcome data in RA patients. Results surviving false discovery rate corrections (equivalent to uncorrected p < 0.0023) are shown in italic font
| CHO/CR | MI/CR | |||||
|---|---|---|---|---|---|---|
| ROI | FSS VAS | DAS-28 swollen | DAS-28 tender | FSS VAS | DAS28 swollen | DAS28 tender |
| Precentral R | 0.716** | 0.782** | 0.678* | 0.705** | 0.048 | 0.126 |
| Precentral L | 0.742** | 0.660* | 0.764** | 0.452 | 0.564* | 0.299 |
| Frontal lobe R | 0.823*** | 0.629* | 0.683* | 0.413 | − 0.111 | − 0.081 |
| Frontal lobe L | 0.674* | 0.672* | 0.759** | 0.615* | 0.425 | 0.156 |
| Rolandic Oper R | 0.708** | 0.799** | 0.653* | 0.427 | − 0.034 | − 0.033 |
| Rolandic Oper L | 0.714** | 0.700** | 0.709** | 0.309 | 0.071 | 0.321 |
| Supp motor area R† | 0.797** | 0.643* | 0.624* | 0.157 | 0.320 | − 0.190 |
| Supp motor area L | 0.686** | 0.598* | 0.672* | 0.627* | 0.235 | 0.131 |
| Insula R | 0.590* | 0.666* | 0.773** | 0.211 | − 0.111 | − 0.360 |
| Insula L | 0.424 | 0.760** | 0.658* | 0.177 | − 0.190 | − 0.354 |
| Anterior cingulum R† | 0.121 | 0.440 | 0.480 | − 0.420 | − 0.403 | − 0.275 |
| Anterior cingulum L | 0.562* | 0.385 | 0.619* | 0.051 | − 0.184 | − 0.268 |
| Mid cingulum R | 0.770** | 0.485 | 0.717** | − 0.093 | − 0.193 | − 0.379 |
| Mid cingulum L | 0.635* | 0.581* | 0.778** | − 0.084 | − 0.340 | − 0.379 |
| Posterior cingulum R† | 0.395 | 0.547 | 0.603* | 0.553 | 0.393 | 0.296 |
| Posterior cingulum L | 0.166 | 0.539 | 0.544 | 0.466 | 0.601* | 0.488 |
| Hippocampus R | 0.590* | 0.473 | 0.709** | 0.509 | 0.357 | 0.198 |
| Hippocampus L | 0.781** | 0.360 | 0.460 | 0.323 | 0.346 | 0.011 |
| Calcarine R | 0.753** | 0.779** | 0.661* | 0.829*** | 0.419 | 0.307 |
| Calcarine L | 0.548 | 0.734** | 0.781** | 0.731** | 0.269 | 0.257 |
| Cuneus R | 0.705** | 0.709** | 0.488 | 0.613* | 0.400 | 0.179 |
| Cuneus L | 0.596* | 0.689** | 0.516 | 0.596* | 0.337 | 0.008 |
| Lingual gyrus R | 0.753** | 0.768** | 0.756** | 0.320 | 0.476 | 0.265 |
| Lingual gyrus L | 0.618* | 0.743** | 0.664* | 0.492 | 0.561* | 0.360 |
| Occipital lobe R | 0.705** | 0.726** | 0.633* | 0.652* | 0.439 | 0.293 |
| Occipital lobe L | 0.764** | 0.677* | 0.650* | 0.756** | 0.309 | 0.112 |
| Fusiform gyrus R | 0.761** | 0.745** | 0.709** | 0.545 | 0.473 | 0.165 |
| Fusiform gyrus L | 0.806*** | 0.615* | 0.695** | 0.427 | 0.346 | 0.153 |
| Postcentral gyrus R | 0.672* | 0.791** | 0.736** | 0.705** | 0.541 | 0.527 |
| Postcentral gyrus L | 0.694** | 0.714** | 0.820*** | 0.582* | 0.660* | 0.455 |
| Parietal lobe R | 0.834*** | 0.706** | 0.683* | 0.683* | 0.476 | 0.268 |
| Parietal lobe L | 0.868*** | 0.675* | 0.678* | 0.672* | 0.281 | 0.095 |
| Precuneus R | 0.663* | 0.700** | 0.692** | 0.627* | 0.504 | 0.240 |
| Precuneus L | 0.551 | 0.706** | 0.770** | 0.320 | 0.332 | − 0.067 |
| Paracentral lobule R | 0.705*a | 0.519a | 0.628* a | 0.342 a | 0.312 a | − 0.018 a |
| Paracentral lobule L | 0.312 | 0.703** | 0.695** | 0.247 | 0.453 | 0.011 |
| Caudate R | 0.278 | 0.283 | 0.354 | 0.205 | − 0.230 | − 0.293 |
| Caudate L | 0.407 | 0.417 | 0.455 | 0.253 | − 0.023 | − 0.036 |
| Putamen R | 0.014 | 0.221 | 0.449 | 0.424 | 0.077 | 0.089 |
| Putamen L | 0.601* | 0.567* | 0.611* | 0.444 | 0.587* | 0.237 |
| Pallidum R | 0.292 | 0.196 | 0.533 | 0.441 | 0.332 | 0.050 |
| Pallidum L | 0.545 | 0.402 | 0.477 | 0.674* | 0.632* | 0.290 |
| Thalamus R | 0.556* | 0.734** | 0.658* | − 0.037 | 0.009 | − 0.156 |
| Thalamus L | 0.573* | 0.451 | 0.304 | 0.388 | 0.315 | 0.139 |
| Temporal lobe R | 0.745** | 0.856*** | 0.695** | 0.480 | 0.453 | 0.232 |
| Temporal lobe L | 0.809*** | 0.731** | 0.678* | 0.399 | 0.128 | − 0.006 |
| Cerebellum | 0.745** | 0.686** | 0.725** | 0.565* | 0.057 | − 0.011 |
VAS visual analog scale
*p < 0.05; **p < 0.01; ***p < 0.001
n = 13 (unless an exception is noted)
an = 12