Table 1.

FACT-Leu questionnaire [18]

Domain	Items, n	Score, range	Questions
Physical well-being	7	0–28	• I have a lack of energy • I have nausea • Because of my physical condition, I have trouble meeting the needs of my family • I have pain • I am bothered by side effects of treatment • I feel ill • I am forced to spend time in bed
Social well-being	7	0–28	• I feel close to my friends • I get emotional support from my family • I get support from my friends • My family has accepted my illness • I am satisfied with family communication about my illness • I feel close to my partner (or the person who is my main support) • I am satisfied with my sex life
Emotional well-being	6	0–24	• I feel sad • I am satisfied with how I am coping with my illness • I am losing hope in the fight against my illness • I feel nervous • I worry about dying • I worry that my condition will get worse
Functional well-being	7	0–28	• I am able to work (include work at home) • My work (include work at home) is fulfilling • I am able to enjoy life • I have accepted my illness • I am sleeping well • I am enjoying the things I usually do for fun • I am content with the quality of my life right now
Leukemia-specific	17	0–68	• I am bothered by fevers • I have certain parts of my body where I experience significant pain • I am bothered by the chills • I have night sweats • I am bothered by lumps or swelling in certain parts of my body (e.g., neck, armpits, or groin) • I bleed easily • I bruise easily • I feel weak all over • I get tired easily • I am losing weight • I have a good appetite • I am able to do my usual activities • I worry about getting infections • I feel uncertain about my future health • I worry that I might get new symptoms of my illness • I have emotional ups and downs • I feel isolated from others because of my illness or treatment
Aggregated domain	Items, n	Score, range	Calculation
FACT-G total	27	0–108	Sum of the physical well-being, social well-being, emotional well-being, and functional well-being scores
FACT-Leu total	44	0–176	Sum of the FACT-G total and the leukemia-specific scores
TOI-FACT-Leu	31	0–124	Sum of the physical well-being, functional well-being, and the leukemia-specific scores

FACT-G Functional Assessment of Cancer Therapy-General, FACT-Leu Functional Assessment of Cancer Therapy-Leukemia, TOI trial outcome index