Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 May 19;10:8261. doi: 10.1038/s41598-020-65006-z

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

SOX2 and IGF1R as prognostic factors in bladder cancer. (a,b) Kaplan–Meier analysis of SOX2 (a) and SOX4 (b) expression with recurrence-free survival in patients from TCGA_BLCA cohort. The significance was examined by log-rank test. *P < 0.05. (c) Kaplan–Meier analysis to assess the correlation of SOX2-high/SOX4-low and SOX2-low/SOX4-high signatures with recurrence-free survival in patients from TCGA_BLCA cohort. The significance was examined by log-rank test. *P < 0.05. (d) Kaplan–Meier analysis of IGF1R expression with recurrence-free survival in patients from TCGA_BLCA cohort. The significance was examined by log-rank test. **P < 0.01. (e) Kaplan–Meier analysis to assess the correlation of SOX2-high/IGF1R-high and SOX2-low/IGF1R-low signatures with recurrence-free survival in patients from TCGA_BLCA cohort. The significance was examined by log-rank test. ***P < 0.001. (f) The schematic model of SOX2-mediated oncogenesis of bladder cancer. SOX2 induces the expression of IGF2 and IGF1R, but suppresses that of IGFBP1, thus promoting AKT phosphorylation, with increased proliferation and survival of bladder cancer cells.