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. 2020 May 19;10:8263. doi: 10.1038/s41598-020-65357-7

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effect of the addition of C. cervicornis extract, dolastane, and ribavirin on ZIKV or CHIKV replication over time. (A) Inhibition of ZIKV replication. (B) Inhibition of CHIKV replication. Monolayers of Vero cells were infected with ZIKV or CHIKV at an MOI of 3 at time zero. At times indicated, extract, dolastane or ribavirin was added to a final concentration of 10 μg/mL for extract or 10 μM/mL, for dolastane or ribavirin. The data were presented by the virus titers in PFU/mL when compared to control cells and are expressed as the mean of three experiments ± standard error. Statistical analysis was performed using the Tukey test in comparison to C. cervicornis extract, dolastane, and ribavirin in each concentration: *p < 0.05; **p < 0.01; ***p < 0.001.