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. 2020 May 19;10:8263. doi: 10.1038/s41598-020-65357-7

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Virucidal effect. (A) Effect on the ZIKV. (B) Effect on the CHIKV. The viral suspension (ZIKV or CHIKV) was incubated with C. cervicornis extract, dolastane, and ribavirin at concentrations of 2.5, 5, and 10 µg/mL for extract or 10 µM for dolastane or ribavirin for 2 h and then added to Vero cells. Viral cytopathic effect was assessed after 72 h of incubation. Data are presented as the percentage of virus titer when compared to control cells and are expressed as the mean of three experiments ± standard error. Statistical analysis was performed using the Tukey test in comparison to C. cervicornis extract, dolastane, and ribavirin in each concentration: *p < 0.05; **p < 0.01; ***p < 0.001.