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. 2020 May 19;10:8263. doi: 10.1038/s41598-020-65357-7

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Evaluation of the synergistic effect in combination of C. cervicornis extract or dolastane with ribavirin on ZIKV or CHIKV replication. (A) Inhibition of ZIKV replication. (B) Inhibition of CHIKV replication. Monolayers of Vero cells were infected with ZIKV at an MOI of 0.1 and subsequently treated with extract and Ribavirin sub-doses (0.5 µg/mL and 0.5 µM, respectively) and concentrations of 10 µg/mL and 10 µM. In addition, the dose combination was also performed at both concentrations for synergism assessment. Evaluation of the synergistic antiviral effect was determined by inhibition of cytopathic effect by plaque assay. Data are presented as the percentage of virus titer when compared to control cells and are expressed as the mean of three experiments ± standard error. Statistical significance following a one-sample t-test is indicated (*p < 0.05; **p < 0.001).