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. 2020 May 19;10:8263. doi: 10.1038/s41598-020-65357-7

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Synergistic effects of ribavirin and extract or dolastane against ZIKV and CHIKV. Synergy distribution plots and score matrix tables calculated by Bliss and Loewe methods for combination effects of ribavirin and extract or dolastane against (A) ZIKV, and (B) CHIKV are shown. Synergy scores are represented as mean ± standard deviation (n = 3). Statistical significance following a one-sample t-test is indicated (*p < 0.05; **p < 0.001).