Table 1.

Cytotoxicity (CC₅₀), anti-ZIKV, or anti-CHIKV profile (EC₅₀) and selectivity index (SI) of dolastane diterpenes.

Compounds		ZIKV		CHIKV
	CC50a(μg or μM)	EC50b(μg or μM)	SIc	EC50b(μg or μM) SIc
Extract	438 μg/mL ± 5.18	2.15 ± 0.22	203	2.45 ± 1.02	178
Dolastane	935 µM/mL ± 11.0	0.75 ± 0.18	1246	1.28 ± 0.47	730
Ribavirin	297 μM/mL ± 4.25	3.95 ± 0.95	75.2	2.42 ± 0.49	122

The mean values ± standard deviations are representative of three independent experiments.

^aConcentration required to reduce 50% cell viability when compared to untreated controls.

^bConcentration that reduced 50% of ZIKV or CHIKV replication when compared to infected and untreated controls.

^cSelectivity index was defined as the ratio between CC₅₀ and EC₅₀.