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. 2020 May 19;10:8292. doi: 10.1038/s41598-020-65169-9

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Comparative response to 80 adenosine nucleotides tested at 100 μM at wild-type and T184I rat P2X2 (mean and SEM, N = 3–6) expressed in Drosophila taste neurons. Wild type (WT) rat P2X2 (data from Fig. 2) at right and T184I mutant at left. Nucleotides are arranged in order of activity relative to the response to ATP in WT. ATP (black) and its derivatives include modifications in the phosphoryl groups (green), the ribose moiety (orange), the adenine base (blue), a combination of two or more of these (white) or are dinucleotides (grey).