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. 2020 May 19;10:8294. doi: 10.1038/s41598-020-65162-2

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Optimization of nanoparticle size, avidity, and drug diffusivity. (A) Progress of MADS in obtaining the optimal solution. (B) Trial points selected by MADS, where the color and size of the points correspond to the value of TD. The smallest point refers to the optimal solution of TD minimization problem (shown by the arrow).