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. 2020 May 19;11:2506. doi: 10.1038/s41467-020-16052-8

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a The qRT-PCR results display ESRRG mRNA expression levels in primary human prolactinoma cells transfected with control or specific ESRRG siRNA. GAPDH was used as an internal control (n = 3 per group). b Suppression of PRL secretion in primary human prolactinomas cells after ESRRG knockdown using ESRRG siRNA (n = 9 per group). c Results of CCK-8 cell proliferation assay in GH3 cells infected with Ad-null, Ad-canonical ESRRG, and Ad-cryptic ESRRG (n = 5 per group). d Results of CCK-8 cell proliferation assay in MMQ cells infected with Ad-null, Ad-canonical ESRRG, and Ad-cryptic ESRRG (n = 5 per group). e Focus formation was assessed in GH3 cells infected with Ad-null, Ad-canonical ESRRG and Ad-cryptic ESRRG (n = 9 per group). f Focus formations were assessed in MMQ cells infected with Ad-null, Ad-canonical ESRRG, and Ad-cryptic ESRRG (n = 9 per group). g Annexin V/PI staining and flow cytometry showed the percentages of apoptosis of the GH3 cells infected with Ad-null, Ad-canonical ESRRG, and Ad-cryptic ESRRG (n = 9 per group). h Annexin V/PI staining and flow cytometry showed the percentages of apoptosis of the MMQ cells infected with Ad-null, Ad-canonical ESRRG, and Ad-cryptic ESRRG (n = 9 per group). Results are expressed as mean ± SD. The p values by one-way ANOVA followed by Dunnett’s multiple comparisons test in a, b and followed by Tukey’s multiple comparisons post hoc test in c–h are indicated. Source data are provided as a Source Data file.