Table 1.
Clinical characteristics of prolactinoma patients.
| Characteristic | Wild type | Mutant | P value |
|---|---|---|---|
| Age at diagnosis (year) | |||
| Median | 38.00 | 39.00 | 0.45# |
| Interquartile range | 21.75 | 16.00 | |
| Sex (case) | |||
| Male | 115 | 37 | 0.02* |
| Female | 67 | 8 | |
| PRL (ng ml−1)/tumor size (cm)‡ | |||
| Median | 288.12 | 385.58 | 0.02# |
| Interquartile range | 398.19 | 552.11 | |
| Tumor invasion (case) | |||
| Non-invasion | 84 | 27 | 0.10* |
| Invasion | 75 | 13 | |
| Tumor size (cm)‡ | |||
| Median | 2.80 | 2.60 | 0.74# |
| Interquartile range | 1.60 | 2.03 | |
Age and sex data were available for 182 patients with no mutation and 45 patients with the mutation. PRL/tumor size, tumor invasion, and tumor size data were available for 159 patients with no mutation and 40 patients with mutation. In total, 28 cases from the First Affiliated Hospital of University of Science and Technology of China were excluded from statistical analysis because of different PRL dilution measurement protocol.
#Values were compared by two-tailed Mann–Whitney U test.
*Values were compared by Pearson’s χ2 test.
‡Tumor size: maximal tumor diameter.
Source data are provided as a Source Data file.