Fig. 4. The mRNA expression of CNR1 gene and methylation level of cg02498983 is differentially correlated with age in the PFC of Caucasian controls by rs4680 genotype.
In the PFC of Caucasian controls who are COMT Val158 homozygotes, the expression of CNR1 gene and full-length transcript is most negatively correlated with age. Our qPCR results also validated this finding. Interestingly, the methylation level of cg02498983 is most positively correlated with age in the PFC of Caucasian controls who are COMT Val158 homozygotes. Each dot represents a control subject: green line, rs4680 Met/Met genotype; orange line, rs4680 Val/Met genotype; purple line, rs4680 Val/Val genotype. Blue line represents the lifespan trajectory of the methylation level of cg02498983 in PFC.