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. 2020 May 19;10:8278. doi: 10.1038/s41598-020-65211-w

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The effect of delivery of constant positive current into the bilateral STN on L-dopa-induced dyskinesia in parkinsonian rats. (a) Time courses of AIMs score (mean ± SEM) at 20, 40, 60, 80 and 120 minutes after two consecutive L-dopa challenge injections, one with and the other without delivery of constant positive current (150 µA) into the bilateral STN in the same rats as those in Fig. 2. (b) The sum of the global AIMs scores in these parkinsonian rats at baseline and during bilateral STN injection of constant positive current (150 µA). (c) Changes in the sum of the global AIMs scores in L-dopa-induced dyskinesia parkinsonian rats during sham and bilateral STN constant positive current injection at 75, 150 and 300 μA (n = 5, *p < 0.05).