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. 2020 May 19;10:8278. doi: 10.1038/s41598-020-65211-w

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The effect of constant positive current delivered into the STN on the electrophysiological activity of subthalamic neurons in vivo in parkinsonian rats with L-dopa-induced dyskinesia. Sample sweeps of the STN firing pattern (a)before, (b)during and (c) 5 minutes after cessation of 150 µA of constant positive polarity current into the STN. The number of burst firing counts per 30 seconds had already increased significantly with (d–f) 75 µA of current (n = 6) and increased even more with 150 µA (n= 7) or 300 µA (n = 3) of constant current delivered into the bilateral STN (*p < 0.05).