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. 2020 May 19;10:8278. doi: 10.1038/s41598-020-65211-w

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The effect of constant positive current delivered into the bilateral STN on hyperkinesia induced by bilateral intrastriatal 3-NP injection. Sample traces of locomotor activity during (a) sham stimulation and (b) delivery of 150 µA of constant positive constants into the STN. Average locomotor activity, including (c) movement distance, (d) movement duration and (e) rearing score, were all decreased by the constant positive current delivered into the STN (n = 18 for sham stimulation in the six rats, n = 6 for the others, *p < 0.05 compared to sham stimulation). The differences between any two of the three “doses” of the injected current, however, are not statistically significant.