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. 2020 May 19;10:8278. doi: 10.1038/s41598-020-65211-w

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Electrophysiological changes before, during and after delivery of constant positive current into the bilateral STN in rats with 3-NP-induced hyperkinesia. Sample sweeps of the STN firing pattern (a) before, (b) during, and (c) after delivery of 450 µA of constant positive current into the STN. (d–g) Burst counts per 30 seconds tended to increase during stimulation with 150–450 µA current but not with 75 µA current. However, statistical significance was achieved only with 450 µA stimulation (n = 5 in two rats for each current intensity, *p < 0.05 compared with the baseline data before stimulation).