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. 2020 May 19;3:246. doi: 10.1038/s42003-020-0973-6

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a PCA of endometabolite profiling with PC1 against PC2. Red: whole kidney lysate, green: cells grown in 2D, blue: cells grown in 3D, turquoise: isolated distal tubules from perfused kidneys, and pink: pooled quality control sample. Replicates are highlighted as individual dots; shaded area shows the 95% confidence interval. b Heat map and cluster analysis of endometabolites. Range-scaled z-scores of annotated features with a q-value < 0.05 according to ANOVA and FDR correction. Differently abundant metabolite clusters after Pearson and Ward reflect the differences between cultured 2D or 3D grown mIMCD3 cells and kidney lysates. Green: 2D grown cells, red: whole kidney lysate, blue: 3D grown mIMCD3 cells, turquoise: isolated nephrons, n for nephrons = 3, n for 2D, 3D, and kidneys = 4.