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. 2020 May 19;10:8254. doi: 10.1038/s41598-020-65103-z

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Schematic of experimental timeline Scheme of optical system for reflectance measurement. (a) Schematic of tear glucose sensing contact lens preparation, dehydration, measurement and study procedures in both calibration experiments. (b) Integrating sphere and the holder. The integrating sphere has a sphere with a diameter of 30 mm and 6 mm sample port. The tear glucose contact lens sensor is placed on the black plate. Photograph of the 3D printed holder and tear glucose contact lens sensor. (c) 3D structure of the reflectance spectrometer system. Tungsten halogen lamp is coupled with 600 µm fiber and spectrometer is coupled with 1000 µm fiber core diameter.