Table 4.

Grades 3/4 toxicity profile

	Category	< 65 years		≥ 65 years
		Case (n = 16)	Control (n = 16)	Case (n = 8)	Control (n = 8)
Hematologic	Neutropenia	5 (31.3)	12 (75.0)	4 (50.0)	5 (62.5)
	Neutropenic fever	2 (12.5)	3 (18.8)	1 (12.5)	2 (25.0)
	Anemia	1 (6.25)	1 (6.25)	1 (12.5)	1 (12.5)
	Thrombocytopenia	3 (18.8)	1 (6.25)	4 (50.0)	1 (12.5)
Non-hematologic	Diarrhea	1 (6.25)		1 (12.5)
	Pneumonia			3 (37.5)a	2 (25.0)
	Heart failure		1 (6.25)	1 (12.5)	1 (12.5)
	Sepsis	1 (6.25)	1 (6.25)	1 (12.5)b	2 (25.0)
	Brain abscess	1 (6.25)c
	Meningitis			1 (12.5)d

^aInvasive pulmonary aspergillosis

^bHemolytic streptococci-induced sepsis

^cBacteria-induced brain abscess

^dBacteria-induced meningitis